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Related Experiment Video

Updated: Feb 5, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

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Comparing Schizophrenia Patients With a Predicted High/Low Risk of Nonresponse Receiving Treatment with Ziprasidone

Rebecca Schennach^1,2, Michael Riedel^1,3, Ilja Spellmann^1,4

¹Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany.

Pharmacopsychiatry

|September 21, 2018

Summary

Most schizophrenia patients predicted high risk for antipsychotic nonresponse. Ziprasidone and haloperidol showed similar efficacy, but haloperidol caused more side effects.

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Published on: June 15, 2011

Area of Science:

Psychiatry
Clinical Pharmacology

Background:

Assessing antipsychotic treatment response in schizophrenia is crucial.
Predicting nonresponse aids personalized treatment strategies.

Purpose of the Study:

Evaluate antipsychotic treatment response in schizophrenia patients stratified by predicted nonresponse risk.
Compare the efficacy and tolerability of ziprasidone versus haloperidol.

Main Methods:

Double-blind, randomized study of 112 schizophrenia patients.
Weekly assessments using PANSS, GAF, SOFAS, SAS, and HAS.
Patients categorized by predicted high/low risk of nonresponse.

Main Results:

82% of patients were predicted to have a high risk of nonresponse.
No significant difference in PANSS improvement between ziprasidone and haloperidol for high-risk patients or the total sample.
Haloperidol showed significantly higher Simpson-Angus Scale (SAS) and Hillside Akathisia Scale (HAS) scores.

Conclusions:

A high proportion of schizophrenia patients face a significant risk of nonresponse to antipsychotic medications.
Ziprasidone and haloperidol demonstrate comparable efficacy, but haloperidol is associated with increased extrapyramidal side effects.