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Updated: Feb 5, 2026

Design and Optimization Strategies of a High-Performance Vented Box
Published on: June 9, 2023
New Governance Mechanisms to Optimize Protocol Design
Kenneth A Getz1, Jennifer Kim1, Stella Stergiopoulos1
11 Tufts Center for the Study of Drug Development, Tufts University, Boston, MA, USA.
Abstract:
Pharmaceutical and biotechnology companies are actively seeking ways to optimize protocol design. An emerging approach has been the creation of a new governance mechanism designed to evaluate protocol feasibility and simplify design before final protocol approval. In late 2012, the Tufts Center for the Study of Drug Development conducted a qualitative in-depth assessment of 10 major pharmaceutical companies that have implemented these new governance mechanisms since 2009. Detailed profiles of each company's feasibility review mechanism are discussed including committee missions and objectives, positioning, composition, staffing models, reporting flow, implementation challenges, and measured impacts to date.
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