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Meta-analysis of correlationship between HLA-G 3'UTR 14-bp Ins/Del polymorphism and virus susceptibility
Haiyan Lv1, Huizhi Lv, Zhong Lin
1Public Laboratory, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai Anesthesia Deparment, Sanmen People's Hospital, Sanmen Pharmacy Department Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Background:
There is a considerable amount of literature on the potential relationship between human leukocyte antigen-G 14-bp Ins/Del polymorphism and virus infection; however, results from these studies were inconclusive.
Objectives:
A meta-analysis was carried out to determine whether the 14-bp Ins/Del polymorphism is a susceptible factor for virus infection.
Methods:
Data were extracted from PubMed and Web of Science databases, and included 10 case-control studies (1835 patients and 2357 controls).
Results:
A total of 177 records from 10 studies were retrieved. Overall, no significant correlation was found between HLA-G 14-bp Ins/Del polymorphism and total viruses under all genetic models (dominant model: OR = 0.93, 95% CI = 0.68-1.29; recessive model: OR = 1.12, 95% CI = 0.84-1.48; deletion/deletion (DD) vs insertion/insertion (II): OR = 1.03, 95% CI = 0.71-1.49; deletion (D) vs insertion (I): OR = 1.01, 95% CI = 0.81-1.25). However, further subgroup analyses by virus type and ethnicity revealed that HLA-G 14-bp Ins/Del polymorphism was significantly associated with HTLV-1 infection in mixed population under the dominant model.
Conclusions:
Our study demonstrated that HLA-G 14-bp Ins/Del polymorphism may not have any effect on susceptibility to viruses.
Insights
The human leukocyte antigen-G 14-bp Ins/Del polymorphism is not generally linked to virus infection susceptibility. However, a specific association was found with HTLV-1 infection in mixed populations.
Area of Science:
- Immunogenetics
- Virology
- Genetic Epidemiology
Background:
- The role of human leukocyte antigen-G (HLA-G) 14-bp insertion/deletion (Ins/Del) polymorphism in viral infections remains unclear.
- Previous studies on this association have yielded inconclusive results.
Purpose of the Study:
- To conduct a meta-analysis to determine if the HLA-G 14-bp Ins/Del polymorphism is a risk factor for viral infections.
- To synthesize existing evidence and provide a more definitive conclusion on the genetic association.
Main Methods:
- A systematic literature search was performed on PubMed and Web of Science.
- Included 10 case-control studies comprising 1835 patients and 2357 controls.
- Meta-analysis was conducted using various genetic models (dominant, recessive, deletion/deletion vs. insertion/insertion, deletion vs. insertion).
Main Results:
- Overall, no significant correlation was found between HLA-G 14-bp Ins/Del polymorphism and total viral infections across all genetic models.
- Subgroup analyses indicated a significant association between the HLA-G 14-bp Ins/Del polymorphism and HTLV-1 infection in mixed populations under the dominant model.
Conclusions:
- The HLA-G 14-bp Ins/Del polymorphism does not appear to influence susceptibility to most viral infections.
- A potential specific association with HTLV-1 infection warrants further investigation.