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Updated: Feb 5, 2026

Transplantation of Cells Directly into the Kidney of Adult Zebrafish
Published on: May 18, 2011
Autologous Transplantation for Older Adults with AML
Beatrice U Mueller1, Katja Seipel2, Ulrike Bacher3
1Department of BioMedical Research, University of Bern, 3010 Berne, Switzerland. beatrice.mueller@insel.ch.
Abstract:
While the majority of patients with acute myeloid leukemia (AML) are above the age of 65 years at diagnosis, the outcome of older AML patients remains disappointing. Even if standard intensive chemotherapy induces morphologic complete remission (CR1), relapses in older AML patients are common leading to poor long-term survival outcomes. Since autologous hematopoietic stem cell transplantation (HCT) offers distinct anti-leukemic effectiveness while avoiding graft-versus-host disease associated with allogeneic transplantation, it represents an option for consolidation treatment in selected older AML patients. However, prospective studies in older AML patients assessing the benefit of autologous HCT compared to chemotherapy consolidation or allogeneic transplantation are lacking. Consequently, clinicians face the dilemma that there is considerable ambiguity on the most appropriate consolidation treatment for older AML patients in CR1. This review highlights the possible role of autologous HCT for consolidation in older AML patients reaching CR1 after induction treatment.
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