Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic nervous system development in hypertensive rats.

R McCarty

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |October 1, 1986
    PubMed
    Summary

    Early life sympathetic nervous system development differs between hypertensive and normotensive rat pups. Spontaneously hypertensive rats show greater cardiac ornithine decarboxylase induction, potentially contributing to lifelong high blood pressure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Peripheral autonomic dysregulation in response to standing: a new form associated with cardiovascular disease, mobility reduction, and cognitive alterations.

    European heart journal·2026
    Same author

    Forebrain binding sites for atrial natriuretic factor: Alterations in spontaneously hypertensive (SHR) rats.

    Neurochemistry international·2010
    Same author

    Developing an assessment tool for acute wounds.

    Community nurse·1999
    Same author

    Enhanced release of norepinephrine in rat hippocampus during spontaneous alternation tests.

    Neurobiology of learning and memory·1999
    Same author

    Altered NGF regulation may link a genetic predisposition for hypertension with hyperactive voiding.

    The Journal of urology·1999
    Same author

    Attenuation of morphine-induced behavioral changes in rodents by D- and L-glucose.

    Neurobiology of learning and memory·1999

    Area of Science:

    • Developmental biology
    • Cardiovascular physiology
    • Neuroendocrinology

    Background:

    • The sympathetic nervous system plays a crucial role in regulating cardiovascular function.
    • Understanding the developmental trajectory of sympathetic responses is vital for identifying early markers of hypertension.
    • Spontaneously hypertensive rats (SHR) serve as a model for human essential hypertension.

    Purpose of the Study:

    • To investigate the functional development of cardiac and adrenal medullary responses to sympathetic nervous system activation in preweanling SHR and Wistar-Kyoto (WKY) rat pups.
    • To compare the early-life development of sympathetic neurotransmission markers between hypertensive and normotensive rat strains.

    Main Methods:

    • Preweanling SHR and WKY rat pups were injected with insulin or saline at various ages (2, 4, 8, 12, 16 days).

    Related Experiment Videos

  • Tissue markers of sympathetic neurotransmission included ornithine decarboxylase (ODC) induction in the heart and epinephrine (EPI) depletion from the adrenal medulla.
  • Animals were euthanized 3 hours post-injection for tissue analysis.

    • Main Results:

    • SHR pups exhibited significantly greater ODC activity induction in the heart at 2, 4, and 8 days of age compared to WKY pups.
    • No significant differences were observed in the adrenal medullary response to insulin-induced hypoglycemia between SHR and WKY pups.
    • These findings suggest strain-specific alterations in cardiac sympathetic development during early postnatal life.

    Conclusions:

    • Altered patterns of sympathetic-target tissue development, specifically cardiac ODC induction, in early life may contribute to the sustained higher arterial pressures observed in SHR throughout life.
    • These developmental differences highlight potential critical windows for intervention in preventing or mitigating hypertension.