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Updated: Feb 5, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma
Abigail E Kaye1, Elizabeth D Hawkes1, Irina I Gout1
1Prince Charles Eye Unit, King Edward VII Hospital, St. Leonard's Road, Windsor SL4 3DR, UK.
Abstract:
Natalizumab is a monoclonal antibody licensed for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is known to increase the potential risk of developing progressive multifocal leukoencephalopathy (PML). There is current debate in the literature regarding its association with malignant melanoma. Herein, we report a case of a 55-year old lady with RRMS for whom natalizumab therapy was being considered by her neurologist. Her medical history included a choroidal melanoma which had undergone successful treatment. Additionally, in this case study we discuss the issues regarding malignant melanoma risk and recurrence with natalizumab treatment.
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