Related Experiment Video

Updated: Feb 5, 2026

Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K

Recovery of Kidney Function in Children Treated with Maintenance Dialysis

Marjolein Bonthuis1, Jérôme Harambat2, Etienne Bérard3

  • 1European Society for Pediatric Nephrology/ European Renal Association-European Dialysis and Transplant Association Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Clinical Journal of the American Society of Nephrology : CJASN
|September 22, 2018
PubMed

Insights

Kidney function recovery occurred in 2% of pediatric dialysis patients within two years. Recovery was more likely in children with vasculitis, ischemic kidney failure, or hemolytic uremic syndrome.

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Kidney Function Recovery

Background:

  • Limited data exists on kidney function recovery in pediatric end-stage kidney disease (ESKD).
  • This study investigated recovery rates and associated factors in a large European cohort of children on maintenance dialysis.

Purpose of the Study:

  • To determine the incidence of kidney function recovery in pediatric patients undergoing dialysis.
  • To identify factors influencing kidney function recovery in this population.

Main Methods:

  • Analysis of data from 6574 European pediatric patients (age <15 years) initiating dialysis between 1990-2014.
  • Recovery defined as dialysis cessation for ≥30 days; analyzed using cumulative incidence and Cox proportional hazard models.

Main Results:

  • 2% of patients (130/6574) recovered kidney function within 2 years of dialysis initiation.
  • Recovery was significantly more common in patients with vasculitis (aHR 20.4), ischemic kidney failure (aHR 11.4), and hemolytic uremic syndrome (aHR 15.6) compared to congenital anomalies.
  • Younger age and hemodialysis initiation were also associated with higher recovery rates. 32% of recoveries were transient.

Conclusions:

  • A 2% recovery rate within 2 years was observed in pediatric dialysis patients.
  • Significant recovery potential exists for children with specific conditions like vasculitis, ischemic kidney failure, and hemolytic uremic syndrome.
  • These findings are crucial for guiding kidney transplantation decisions in pediatric patients.
Abstract

Keywords:
Cohort StudiesESRDEdetic AcidHemolytic-Uremic SyndromeIncidenceKidney Failure, ChronicProportional Hazards ModelsRegistriesRenal Insufficiencychronic dialysiskidneykidney transplantationpediatric nephrologyperitoneal dialysisrenal dialysisrenal function recoveryvasculitis

More Related Videos

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

13.9K
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

16.0K

Related Concept Videos

Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.5K
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.8K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
799
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.3K
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
3.2K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K