Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

24.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.3K
Ligand Binding Sites02:40

Ligand Binding Sites

15.1K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.1K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

5.6K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.6K
Peptide Bonds02:43

Peptide Bonds

83.1K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.1K
Bond Energies and Bond Lengths02:49

Bond Energies and Bond Lengths

31.5K
Stable molecules exist because covalent bonds hold the atoms together. The strength of a covalent bond is measured by the energy required to break it, that is, the energy necessary to separate the bonded atoms. Separating any pair of bonded atoms requires energy — the stronger a bond, the greater the energy required to break it.
31.5K
C–C Bond Formation: Aldol Condensation Overview01:10

C–C Bond Formation: Aldol Condensation Overview

16.3K
Aldol condensation is an important route in synthetic organic chemistry used to generate a new carbon–carbon bond under basic or acidic conditions. The aldol condensation reaction presented in Figure 1 constitutes an aldol addition reaction followed by the dehydration process.
16.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data-Driven Predictions of Diastereoselectivity in Crystallization-Induced Diastereomer Transformations.

Organic letters·2026
Same author

Data Science and High-Throughput Spectroelectrochemistry-Guided Interrogation of Sulfonate Anions for OMIECs.

Journal of the American Chemical Society·2026
Same author

Assessment of Complementary Catalysts in an Uncharted Enantioselective Reaction of Sulfondiimines.

Journal of the American Chemical Society·2026
Same author

Best Practices and Considerations for Applying Multiple Linear Regression in Organic Chemistry Research.

The Journal of organic chemistry·2026
Same author

Transferable enantioselectivity models from sparse data.

Nature·2026
Same author

Correction to "A Data Science-Guided Approach for the Development of Nickel-Catalyzed Homo-Diels-Alder Reactions".

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Feb 5, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

1.2K

Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization.

Shibin Zhao1,2, Tobias Gensch3, Benjamin Murray1,2

  • 1Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA.

Science (New York, N.Y.)
|September 22, 2018
PubMed
Summary

This study clarifies stereochemistry transfer in Suzuki cross-coupling reactions using chiral alkylboron nucleophiles. Researchers developed predictive models to control stereochemical outcomes, enabling precise synthesis of complex molecules.

More Related Videos

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

15.5K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.7K

Related Experiment Videos

Last Updated: Feb 5, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

1.2K
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

15.5K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.7K

Area of Science:

  • Organic Chemistry
  • Stereochemistry
  • Catalysis

Background:

  • Stereospecific cross-coupling reactions offer significant potential for controlling molecular 3D structure.
  • Understanding stereochemistry transfer in these reactions is crucial but remains limited.

Purpose of the Study:

  • To investigate the mechanistic and synthetic aspects of stereospecific palladium-catalyzed Suzuki cross-coupling reactions.
  • To understand and control the factors governing stereochemistry transfer using enantioenriched alkylboron nucleophiles.

Main Methods:

  • Utilized enantioenriched alkylboron nucleophiles in palladium-catalyzed Suzuki cross-coupling.
  • Developed molecular descriptors for phosphine ligands.
  • Applied predictive statistical models to guide ligand selection and design.

Main Results:

  • Identified ligands that promote either stereoinvertive or stereoretentive cross-coupling reactions.
  • Successfully accessed stereodefined branched structures through predictable manipulation of absolute stereochemistry.
  • Proposed a general mechanistic model for alkylboron transmetallation.

Conclusions:

  • Predictive models based on ligand descriptors enable control over stereochemical outcomes in Suzuki couplings.
  • This work provides a method for the predictable synthesis of stereodefined branched organic molecules.
  • A mechanistic understanding of alkylboron transmetallation was advanced.