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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
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Multi-drug-resistant tuberculosis with galaxy and cluster signs on high-resolution computed tomography
Keitaro Nakamoto1, Yuka Sasaki1, Hiroyuki Kokuto1
1Department of Respiratory Medicine Fukujuji Hospital, Japan Anti-Tuberculosis Association Kiyose Japan.
Respirology Case Reports
|September 22, 2018
Summary
The galaxy and cluster signs on CT scans, typically seen in sarcoidosis, can also appear in tuberculosis. Careful examination is crucial to differentiate these conditions, especially with multi-drug-resistant tuberculosis.
Area of Science:
- Radiology
- Pulmonology
- Infectious Diseases
Background:
- The galaxy sign and cluster sign are characteristic computed tomography (CT) findings in pulmonary sarcoidosis.
- These signs are typically associated with sarcoidosis, aiding in its diagnosis.
Observation:
- A case report details a 44-year-old man presenting with fatigue, cough, and fever.
- Thoracic CT revealed the galaxy sign (coalescent small nodules forming a large nodule) and cluster sign (numerous small nodules) in bilateral lungs.
Findings:
- Sputum acid-fast smears were negative, initially suggesting conditions other than tuberculosis.
- Bronchoalveolar lavage fluid culture confirmed Mycobacterium tuberculosis, indicating pulmonary tuberculosis.
- Drug sensitivity testing revealed the tuberculosis to be multi-drug-resistant.
Implications:
- The presence of galaxy and cluster signs on CT scans necessitates careful differential diagnosis.
- It is crucial to distinguish pulmonary tuberculosis from sarcoidosis when these CT findings are observed.
- This case highlights the importance of considering tuberculosis in patients with these radiological signs.
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