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Updated: Feb 5, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride
Chunqi Chen1, Lubin Xu, Liang Wang
1College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China. flyshuaishuai@126.com liangwang0532@yeah.net.
Abstract:
An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.
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