Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases
Ann Brinkmalm1,2, Erik Portelius1,2, Gunnar Brinkmalm1
1Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Journal of Neurochemistry
|September 22, 2018
Summary
Identifying neurodegenerative dementia requires objective biomarkers due to early, non-specific symptoms. Proteomics can help discover new biomarkers for early detection and disease-modifying treatments.
Area of Science:
- Neurology
- Biochemistry
- Proteomics
Background:
- Neurodegenerative dementias involve protein misfolding and accumulation, leading to neuronal damage.
- Clinical symptoms often appear late and correlate poorly with underlying pathology.
- Early intervention is crucial to prevent irreversible neurological damage.
Purpose of the Study:
- To discuss neuropathological changes in neurodegenerative dementias.
- To explore the use of biofluid-based biomarkers for detection and quantification.
- To identify novel biomarkers using targeted proteomics.
Main Methods:
- Review of neuropathological changes in neurodegenerative diseases.
- Analysis of current biofluid-based biomarker detection and quantification methods.
- Discussion of targeted proteomics for identifying new biomarkers.
Main Results:
- Abnormally folded proteins are key in neurodegenerative dementias.
- Biofluid biomarkers can detect and quantify neuropathology.
- Targeted proteomics offers potential for discovering new biomarkers.
Conclusions:
- Objective, biomarker-based measures are essential for developing disease-modifying drugs.
- Early detection via biomarkers, even in the pre-clinical phase, is vital for effective treatment.
- Proteomics can significantly advance the identification of crucial biomarkers for neurodegenerative dementias.
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