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Updated: Feb 5, 2026

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Synthetic Strategies and Structural Arrangements of Isoreticular Mixed-Component Metal-Organic Frameworks
Johannes Bitzer1, Wolfgang Kleist1
1Faculty of Chemistry and Biochemistry, Industrial Chemistry-, Nanostructured Catalyst Materials, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany.
Abstract:
In recent years, the synthesis of mixed-metal and mixed-linker metal-organic frameworks with multiple metals and/or linker molecules combined in one framework has become a growing field of interest. These mixed-component or multivariate metal-organic framework materials provide the possibility to introduce multiple functionalities inside one framework. The interaction of guest molecules with different functionalities in the same material is a promising approach in the fields of gas storage, separation, catalysis and drug delivery. Furthermore, the combination of different components may lead to synergistic effects that cannot be achieved otherwise. These mixed-component approaches open up new pathways to an even larger range of possible customizations in the field of metal-organic frameworks.
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