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Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child
José Ignacio Fernández-Vigo1,2, Bachar Kudsieh2, Lucía De-Pablo-Gómez-de-Liaño2,3
1Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain.
Insights
Fourier-domain optical coherence tomography (FD-OCT) can measure Schlemm's canal (SC) in children. SC size increases with age, but is not affected by gender, refractive error, or anterior chamber angle. Measurements were highly reproducible.
Area of Science:
- Ophthalmology
- Anatomy
- Medical Imaging
Background:
- Schlemm's canal (SC) is a crucial structure in the eye's drainage system.
- Understanding SC dimensions in pediatric populations is important for glaucoma research.
- In vivo measurement of SC in children has been challenging.
Purpose of the Study:
- To measure Schlemm's canal (SC) in vivo using Fourier-domain optical coherence tomography (FD-OCT).
- To assess SC dimensions in a Caucasian pediatric population.
- To investigate correlations between SC size and various ocular parameters.
Main Methods:
- A cross-sectional study involving 290 healthy children.
- FD-OCT (RTVue®) was used to measure SC cross-sectional diameter and area in nasal and temporal quadrants.
- Correlations with age, gender, refractive error, anterior chamber angle, and trabecular meshwork metrics were analyzed. Reproducibility was assessed in 30 participants.
Main Results:
- SC diameters and areas were similar between nasal and temporal quadrants.
- No significant differences in SC measurements were found based on gender, refractive error, or anterior chamber/trabecular meshwork metrics.
- Age was directly correlated with SC size (p ≤ 0.041).
- Measurement reproducibility was excellent (ICC ≥ 0.936).
Conclusions:
- FD-OCT is a viable tool for identifying and measuring the SC in pediatric eyes.
- SC dimensions increase with age in children.
- These findings provide normative data for SC in a pediatric population.
Purpose:
To measure the Schlemm's canal (SC) in vivo by Fourier-domain optical coherence tomography (FD-OCT) in a Caucasian paediatric population.
Methods:
Participants of this cross-sectional study were 290 healthy children. In the right eye of each child, SC cross-sectional diameter and area measurements were made with the FD-OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants.
Results:
Mean participant age was 10.7 ± 3.4 years (range 3-18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131-509) and 273.2 ± 77.3 μm (range 124-486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000-23 000) versus 9688 ± 3297 μm2 (range 3000-24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936).
Conclusion:
FD-OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.