Related Experiment Video
Updated: Feb 5, 2026
03:23
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
1.4K
Respiratory symptoms associated with eosinophilic esophagitis
Eitan Rubinstein1, Rachel L Rosen1
1Aerodigestive Center, Division of Gastroenterology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Pediatric Pulmonology
|September 22, 2018
Summary
Eosinophilic esophagitis (EoE) can cause symptoms outside the esophagus, affecting the airways and voice. Early awareness by specialists is crucial for accurate diagnosis and management.
Area of Science:
- Immunology
- Gastroenterology
- Otorhinolaryngology
Background:
- Eosinophilic esophagitis (EoE) is an atopic condition characterized by eosinophilic infiltration of the esophagus.
- While EoE primarily affects the esophagus, emerging evidence suggests extraesophageal manifestations.
Purpose of the Study:
- To review the medical literature on extraesophageal symptoms associated with EoE.
- To emphasize the importance of recognizing EoE in patients presenting with non-gastrointestinal symptoms.
Main Methods:
- Literature review of studies reporting extraesophageal symptoms in EoE patients.
- Analysis of clinical presentations and diagnostic challenges.
Main Results:
- EoE is associated with symptoms like chronic cough, croup, hoarseness, and subglottic stenosis.
- These symptoms can occur without typical gastrointestinal manifestations.
- Prior treatment with proton pump inhibitors or corticosteroids can complicate diagnosis.
Conclusions:
- Extraesophageal manifestations of EoE are increasingly recognized.
- Increased awareness among pulmonologists and otolaryngologists is vital for timely diagnosis.
- Recognizing EoE outside of typical GI presentations improves patient outcomes.
Related Concept Videos
01:24Esophageal Varices-I: Introduction
1.5K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.5K
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.3K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.3K
01:30Negative and Cognitive Symptoms of Schizophrenia
580
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
580
01:22Esophageal Perforation-I: Introduction
612
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
612
01:30Esophageal Strictures-I: Introduction
879
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
879
01:31Anatomy of Respiratory System II: Lower Respiratory Tract
3.7K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
3.7K