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Updated: Feb 5, 2026
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An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Published on: December 5, 2025
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[Clinical application of Flow-through chimeric anterolateral thigh perforator flap]
Juyu Tang1, Wei Du2, Liming Qing3
1Department of Hand and Microsurgery, Xiangya Hospital, Central South University, Changsha Hunan, 410008, P.R.China.tangjuyu@csu.edu.cn.
Summary
The Flow-through chimeric anterolateral thigh perforator (ALTP) flap offers a reliable solution for complex limb defects. This technique successfully reconstructed severe injuries, demonstrating excellent flap survival and functional outcomes.
Area of Science:
- Microsurgery
- Reconstructive Surgery
- Limb Reconstruction
Background:
- Complex extremity defects pose significant reconstructive challenges.
- Traditional methods may involve vessel sacrifice or multiple stages.
- The anterolateral thigh (ALT) flap is a versatile option for soft tissue reconstruction.
Purpose of the Study:
- To evaluate the feasibility and efficacy of the Flow-through chimeric anterolateral thigh perforator (ALTP) flap.
- To assess its utility in one-stage repair and revascularization of complex limb defects.
- To determine outcomes in patients with exposed bone, joints, tendons, or arterial injury.
Main Methods:
- Six patients with complex limb defects underwent reconstruction using the Flow-through chimeric ALTP flap.
- The technique involved using a muscle flap for deep dead space and a perforator flap for superficial defects.
- Defect characteristics included bone defects, joint/tendon exposure, and arterial injury.
Main Results:
- All six flaps survived without infection or vascular compromise.
- Recipient and donor sites healed primarily, with good flap color and texture.
- Successful revascularization and limb salvage were achieved, with no donor site malfunction.
Conclusions:
- The Flow-through chimeric ALTP flap is a reliable method for reconstructing three-dimensional defects.
- It allows for reconstruction without sacrificing recipient vessels.
- This technique is ideal for complex limb wounds with dead space and potential vascular compromise.
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