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Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
Published on: June 12, 2014
Iron-modulated virulence factors of Entamoeba histolytica
Aurora Gastelum-Martínez1, Claudia León-Sicairos1, Laura Plata-Guzmán1
1Programa Regional del Noroeste para el Posgrado en Biotecnología de la Facultad de Ciencias Químico Biológicas. Universidad Autónoma de Sinaloa. Av. de las Américas y Josefa Ortiz (Cd. Universitaria) Culiacán 80030, Sinaloa, Mexico.
Abstract:
Entamoeba histolytica is a human parasite that causes amoebiasis, a disease that affects the colon and liver and is prevalent worldwide. This protozoan requires a high concentration of iron to survive and reproduce. Iron modulates the expression of parasite virulence factors, including hemoglobinases, hemoglobin-binding proteins and cysteine proteases, as well as proteins related to the amoebic cytoskeleton. This review summarizes the virulence factors that are affected by iron, resulting in upregulation or downregulation of E. histolytica genes. This review also discusses the functionality of iron in the mechanisms of pathogenesis.
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