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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Related Experiment Video

Updated: Feb 5, 2026

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System
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IgG lymphoplasmacytic lymphoma: a case report.

Inès Vergnolle1, Nicolas Sigur2, Jill Corre1

  • 1Laboratoire d'hématologie, CHU de Toulouse, IUC-T, Toulouse, France.

Annales De Biologie Clinique
|September 22, 2018
PubMed
Summary

Lymphoplasmacytic lymphoma (LPL) is rare, with most cases secreting IgM. This article details a rare IgG-secreting LPL case, highlighting diagnostic challenges in hematology.

Keywords:
MYD88 L265Pimmunoglobulin Glymphoplasmacytic lymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Lymphoplasmacytic lymphoma (LPL) is an uncommon lymphoproliferative disorder.
  • Most LPL cases are associated with Waldenström macroglobulinemia, characterized by immunoglobulin M (IgM) paraprotein production.
  • Rare variants involve immunoglobulin A (IgA) or immunoglobulin G (IgG) secretion, presenting diagnostic complexities.

Observation:

  • A recent case of lymphoplasmacytic lymphoma was diagnosed at the University Hospital of Toulouse.
  • This specific case involved the secretion of immunoglobulin G (IgG).

Findings:

  • The diagnosed case was identified as an IgG-secreting lymphoplasmacytic lymphoma.
  • This finding represents a rare exception to the typical IgM-secreting Waldenström macroglobulinemia.

Implications:

  • Describing rare IgG-LPL cases improves understanding of LPL heterogeneity.
  • Accurate diagnosis of IgG-LPL is crucial for appropriate patient management.
  • Further research into rare LPL variants is warranted to refine diagnostic and therapeutic strategies.