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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Coronary Circulation01:21

Coronary Circulation

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
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Overview of Pulmonary Circulation01:19

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The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
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Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

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The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Separation of Sister Chromatids02:17

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At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
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Related Experiment Video

Updated: Feb 5, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Separating fetal and maternal placenta circulations using multiparametric MRI.

Andrew Melbourne1,2, Rosalind Aughwane1,3, Magdalena Sokolska4

  • 1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.

Magnetic Resonance in Medicine
|September 22, 2018
PubMed
Summary

This study introduces a new MRI model to analyze placental blood flow, offering insights into pregnancy health. The method successfully differentiates maternal and fetal circulation, aiding in understanding placental function in disease.

Keywords:
DECIDEchoriondiffusionflow-matchingrelaxometry

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Related Experiment Videos

Last Updated: Feb 5, 2026

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Isolation of Leukocytes from the Human Maternal-fetal Interface
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Area of Science:

  • Medical Imaging
  • Obstetrics
  • Biophysics

Background:

  • The placenta is crucial for fetal-maternal exchange, and its pathologies can impact pregnancy outcomes.
  • Understanding placental flow dynamics is vital for assessing pregnancy progression and identifying potential complications.

Purpose of the Study:

  • To develop and validate a novel multiparametric Magnetic Resonance Imaging (MRI) model for placental tissue signal analysis.
  • To characterize fetal and maternal blood flow properties within the placenta using advanced MRI techniques.

Main Methods:

  • A 3-compartment model (fast/slow fluid pools, tissue pool) was fitted to overlapping multiecho T2 relaxometry and low b-value diffusion MRI data.
  • The combined model and acquisition were implemented on a 1.5 Tesla clinical MRI system, with a total acquisition time under 20 minutes.

Main Results:

  • The study measured mean T2 relaxation times for myometrium, maternal blood, and fetal blood components in control placentas.
  • Key parameters such as the maternal-to-fetal blood volume ratio (1.16 ± 0.6) and mean fetal blood saturation (72.93 ± 20.11%) were determined.

Conclusions:

  • The novel MRI acquisition enables measurement of histologically relevant physical parameters, including vascular space proportions.
  • This technique holds potential for a deeper understanding of placental physiological properties and their alterations in disease states.