Related Experiment Video
Updated: Feb 5, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Closing the Loop: Triazolylpyridine Coordination Drives the Self-Assembly of Metallomacrocycles with Tunable
Caitlin E Miron1, Madelaine R Colden Leung1, Emily I Kennedy1
1Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, ON, K7L 3N6, Canada.
Abstract:
The 2-(1,2,3-triazol-4-yl)pyridine motif, with its facile "click" synthesis and remarkable coordinative properties, is an attractive chelate for applications in the metal-directed self-assembly of intricate three-dimensional structures. Organic ligands that bear two such chelates bridged by flexible hinge moieties readily undergo self-assembly with metal ions of different coordination geometries to generate a series of topologically diverse metallomacrocycles that can be used for numerous applications. Herein, the synthesis and self-assembly of one such ligand with zinc(II), copper(II), and palladium(II) ions is reported, and the stability of the resulting metallomacrocycles described. An investigation into the use of these metallomacrocycles for the recognition of both small-molecule substrates, such as deoxyguanosine monophosphate, and larger biological assemblies, such as DNA and RNA guanine quadruplexes, is also described.
Related Concept Videos
Open and closed-loop control systems
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
Coordination Number and Geometry
Coordination Compounds and Nomenclature
Lattice Centering and Coordination Number
Types of Unit Cells
Imagine taking a large number of identical...
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Equations of Motion: Rectangular Coordinates and Cylindrical Coordinates
When a particle moves relative to an inertial frame, the equations of motion can be expressed using rectangular components. If the motion is confined to the x-y plane, the equations having the x and y coordinates only can be used to simplify the mathematical representation.
However, when particles...

