Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

424
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
424
Clinical Trials01:16

Clinical Trials

10.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.7K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.6K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.6K
Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

95.4K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
95.4K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

101.8K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
101.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detecting and Mitigating Bias for Inclusive and Trustworthy Clinical Research: A Scientific Statement From the American Heart Association.

Circulation. Genomic and precision medicine·2026
Same author

Extracorporeal Right Internal Mammary Artery to Radial Graft for Minimally Invasive Total Arterial Coronary Bypass.

Annals of thoracic surgery short reports·2026
Same author

The Society of Thoracic Surgeons 2026 Clinical Practice Guidelines for the Prevention and Treatment of New-Onset Postoperative Atrial Fibrillation After Cardiac Surgery.

The Annals of thoracic surgery·2026
Same author

Patterns and Outcomes of Completeness of Revascularization in Patients With Diabetes and Non-ST-Segment-Elevation Myocardial Infarction in Ontario, Canada.

Circulation. Population health and outcomes·2026
Same author

Adjunctive pharmacological strategies for residual risk reduction after myocardial revascularisation.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

Propensity-matched analysis of the impact of saphenous vein graft external stenting on clinical outcomes in coronary bypass surgery: The RESTART study.

JTCVS open·2025
Same journal

Contemporary medical management of left ventricular assist device patients: integrating sex-specific perspectives.

Current opinion in cardiology·2026
Same journal

Viability testing for guiding revascularization in ischemic cardiomyopathy.

Current opinion in cardiology·2026
Same journal

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

Current opinion in cardiology·2026
Same journal

Rebooting blood vessel repair: implications of the SEMA-VR CardioLink-15 trial.

Current opinion in cardiology·2026
Same journal

Advancements in wearable technology for heart failure patients.

Current opinion in cardiology·2026
Same journal

Minimally invasive approaches to coronary artery bypass grafting: techniques, current evidence, and future directions.

Current opinion in cardiology·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

3.3K

The ROMA trial: why it is needed.

Mario F L Gaudino1, David P Taggart2, Stephen E Fremes3

  • 1Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York City, New York, USA.

Current Opinion in Cardiology
|September 22, 2018
PubMed
Summary
This summary is machine-generated.

Multiple arterial grafts may improve outcomes in coronary bypass surgery, but evidence is mixed. The Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts (ROMA) trial aims to clarify the benefits of using multiple arterial grafts.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

3.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
07:56

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

3.3K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

3.2K

Area of Science:

  • Cardiovascular Surgery
  • Clinical Trials
  • Grafting Techniques

Background:

  • Observational studies suggest superior outcomes with multiple arterial grafts in coronary bypass.
  • Existing randomized evidence is inconclusive, with conflicting results from interim analyses and pooled data.

Purpose of the Study:

  • To review current evidence on single vs. multiple arterial grafts for coronary bypass.
  • To highlight the significance of the Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts (ROMA) trial.

Main Methods:

  • Analysis of observational data on clinical outcomes.
  • Review of randomized controlled trials, including interim results and pooled analyses.
  • Focus on the design and objectives of the ROMA trial.

Main Results:

  • Observational data favors multiple arterial grafts.
  • Randomized data shows no benefit for bilateral internal thoracic arteries but suggests benefit for radial artery as a second graft.
  • Contradictions attributed to confounders, biases, and methodological flaws.

Conclusions:

  • The ROMA trial was designed to resolve conflicting evidence regarding multiple arterial grafts.
  • A definitive answer on the clinical benefit of multiple arterial grafts is sought.