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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Uterine stem cells: from basic research to advanced cell therapies.

Xavier Santamaria1,2,3, Aymara Mas1,4, Irene Cervelló5

  • 1Reproductive Medicine Department, Igenomix Academy, Paterna (Valencia), Spain.

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Uterine stem cell research is advancing, offering new cell-based therapies for incurable uterine conditions like Asherman syndrome and atrophic endometrium. Bone marrow-derived stem cells (BMDSCs) show promise in treating these pathologies.

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Area of Science:

  • Reproductive biology
  • Stem cell science
  • Regenerative medicine

Background:

  • Stem cell research has identified endometrial and myometrial stem cells and their niches in humans and animal models.
  • This foundational knowledge is paving the way for clinical applications in treating incurable uterine diseases.
  • Bone marrow-derived stem cells (BMDSCs) are also implicated in uterine physiology, offering an external and autologous stem cell source.

Purpose of the Study:

  • To review the progress of endometrial and myometrial stem/progenitor cells from characterization to clinical application.
  • To highlight their roles in conditions such as Asherman syndrome, atrophic endometrium, and tissue engineering.
  • To explore the potential of stem cells in uterine regeneration and pathology.

Main Methods:

  • A comprehensive literature search of PubMed and Google Scholar up to December 2017 was performed.
  • The search focused on peer-reviewed literature concerning stem cells (bone marrow, endometrial, myometrial) and their contribution to uterine physiology and pathology.
  • The review synthesizes findings on stem cell characteristics, niches, and therapeutic implications.

Main Results:

  • The discovery and characteristics of endometrial and myometrial stem cells in humans and mice are presented, along with the significance of their niches.
  • Current stem cell therapies using BMDSCs for Asherman syndrome and atrophic endometrium are analyzed.
  • Understanding of stem cell defects in uterine leiomyoma development and advances in tissue engineering for uterine transplantation are discussed.

Conclusions:

  • Knowledge of uterine stem cells and their niches is translating into novel cell-based therapeutic strategies for currently incurable uterine pathologies.
  • While further research and improvements are necessary, a solid foundation for therapeutic applications of uterine stem cells has been established.
  • Stem cell research offers a promising avenue for treating conditions unresponsive to conventional drug therapies.