The "Wiser" oncoplastic reduction mammaplasty - An approach to challenging medial defects
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Updated: Oct 13, 2026

Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Published on: January 3, 2013
Xiao Zhu1, Francesco M Egro1, Carolyn De La Cruz1
1Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Abstract:
Medial defects created by breast-conservation surgery pose a significant challenge to oncoplastic reduction mammaplasty, especially with superficial tumors that necessitate resection of overlying skin. These tumors lie outside of the standard breast reduction excision pattern, and require modifications to the routine Wise approach. We present one modification - the "Wiser" oncoplastic reduction mammaplasty technique - that utilizes spared tissue along the lower pole, and a medial dermoglandular pedicle to address both skin and parenchymal defects created by the tumor resection.
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