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Improving decision-making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized
Sebastien Guillaume1,2, Aurélia Gay3,4, Isabelle Jaussent2
1Department of Psychiatric Emergency and Acute Care, Lapeyronie Hospital, CHRU Montpellier, Montpellier, France.
Repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) improved decision-making and inhibitory control in women with bulimia nervosa (BN). These cognitive enhancements suggest rTMS may be a viable treatment for BN.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Impaired decision-making and inhibitory control are implicated in the pathophysiology of bulimia nervosa (BN).
- Neuromodulation techniques like rTMS may improve these cognitive deficits, potentially leading to clinical improvement in BN.
Purpose of the Study:
- To assess the effects of repetitive transcranial magnetic stimulation (rTMS) on decision-making and inhibitory control in women with BN.
- To investigate if improvements in cognitive functions correlate with potential clinical benefits for BN.
Main Methods:
- A sample of 39 women with BN received 10 sessions of high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) or a sham procedure.
- Cognitive functions, including inhibitory control (go/no-go task, BIS cognitive impulsivity) and decision-making (Iowa gambling task), were assessed before and after the intervention.
Main Results:
- Within-group analyses revealed significant improvements in inhibitory control and decision-making exclusively in the rTMS group.
- Specifically, the rTMS group showed enhanced performance on the go/no-go task, BIS cognitive impulsivity, and the Iowa gambling task.
Conclusions:
- Preliminary findings suggest that modulating the left DLPFC via rTMS can improve key cognitive functions in individuals with BN.
- These cognitive improvements may represent potential biomarkers for BN and suggest rTMS as a promising therapeutic approach.
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