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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Active Surveillance for Localized Prostate Cancer: Nationwide Observational Study.

Frederik B Thomsen1, Henrik Jakobsen2, Niels Christian Langkilde3

  • 1Copenhagen Prostate Cancer Center, Copenhagen, Denmark.

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|September 22, 2018
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Summary
This summary is machine-generated.

Active surveillance for localized prostate cancer shows excellent long-term survival outcomes. This nationwide study supports its use, even for men with favorable intermediate-risk prostate cancer.

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Area of Science:

  • Oncology
  • Urology
  • Public Health

Background:

  • Active surveillance is a management strategy for localized prostate cancer.
  • Understanding long-term survival outcomes is crucial for guiding treatment decisions.

Purpose of the Study:

  • To investigate nationwide survival outcomes in men with localized prostate cancer managed on active surveillance.
  • To assess the safety and efficacy of active surveillance in a large cohort.

Main Methods:

  • A nationwide cohort of 936 men with localized prostate cancer initiated on active surveillance in Denmark (2002-2012) was analyzed.
  • Kaplan-Meier methods were used to estimate survival rates, including curative treatment-free, hormonal therapy-free, castration-resistant prostate cancer-free, and cause-specific survival.
  • Patients were stratified by risk classification: very low, low, intermediate, and high risk.

Main Results:

  • The 10-year cause-specific survival was 99.6%.
  • 10-year curative treatment-free survival was 62.8%, hormonal therapy-free survival was 92.2%, and castration-resistant prostate cancer-free survival was 97.2%.
  • Men with intermediate-risk prostate cancer had higher curative treatment-free survival but lower hormonal therapy-free survival compared to low-risk men.

Conclusions:

  • Nationwide survival outcomes for localized prostate cancer on active surveillance are comparable to prospective cohorts.
  • Active surveillance is a viable management option for men with localized prostate cancer, including those with favorable intermediate-risk disease.