Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Cell Specific Gene Expression

Cell Specific Gene Expression

Structural Organization of the Human Body: An Overview

Structural Organization of the Human Body: An Overview

It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...

Organic Compounds

Organic Compounds

All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...

Organization of Genes

Organization of Genes

Levels of Organization

Levels of Organization

Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Circumferential strain recovery after human cardiomyocyte transplantation in minipigs using a novel frequency-based method for myocardial tagging quantification.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026

Same author

Benzalkonium Chloride-Induced Nephrotoxicity in 2D Cultures and a Human Kidney-on-a-Chip System.

Environmental science & technology·2026

Same author

Cell-type specific allelic dampening of sex-linked genes in sex chromosome aneuploidy.

bioRxiv : the preprint server for biology·2026

Same author

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Aging cell·2026

Same author

Nanopatterned Cell Sheet Assembly of Biomimetic Cardiac Laminae for Modeling Structure-Function Relationships.

Biomaterials research·2026

Same author

Reliable Identification of Cardiac Maturation Markers Using Robust and Flexible Label-Free Proteomic Quantitation by Spectral Counting on Relatively Abundant Proteins.

Journal of proteome research·2026

Search research articles

Related Experiment Video

Updated: Feb 5, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Human Organ-Specific Endothelial Cell Heterogeneity.

Raluca Marcu¹, Yoon Jung Choi¹, Jun Xue¹

¹Department of Bioengineering, University of Washington, Seattle, WA, USA.

|September 22, 2018

Summary

This summary is machine-generated.

Human endothelial cells (ECs) from different organs exhibit unique gene expression and functional properties, crucial for organ development and function. This heterogeneity offers therapeutic potential for organ regeneration and disease modeling.

Keywords:

Biology of Human Development Developmental Biology Stem Cells Research

More Related Videos

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Feb 5, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Area of Science:

Developmental Biology
Cell Biology
Vascular Biology

Background:

The endothelium forms early in embryonic development, establishing circulatory networks.
Endothelial cells (ECs) acquire organ-specific properties to support diverse organ functions.
Understanding EC heterogeneity is key to comprehending organ development and function.

Purpose of the Study:

To investigate the distinct properties of human endothelial cells (ECs) from major organs.
To analyze gene expression and cellular functions of fetal ECs at three months' gestation.
To establish the link between EC heterogeneity and organ development.

Main Methods:

Isolation of endothelial cells from fetal human heart, lung, liver, and kidneys.
Analysis of gene expression patterns.
Assessment of cellular functions including barrier properties, angiogenic potential, and metabolic rate.

Main Results:

Organ-specific ECs display distinct gene expression profiles.
These distinct profiles correlate with specific organ development and functions.
ECs showed varied barrier properties, angiogenic potential, and metabolic rates across organs.

Conclusions:

Human endothelial cells exhibit significant heterogeneity based on organ origin.
This heterogeneity is linked to specific organ development and function.
Findings can inform therapeutic strategies for organ regeneration, disease modeling, and stem cell differentiation.