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Related Experiment Video

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Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
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SGLT1 inhibition: Pros and cons.

Vasilis Tsimihodimos1, Sebastien Filippas-Ntekouan1, Moses Elisaf1

  • 1Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

European Journal of Pharmacology
|September 22, 2018
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Summary

Inhibiting Sodium Glucose Cotransporters 1 (SGLT1) lowers blood glucose but carries risks. This review explores the dual effects of SGLT1 inhibition, highlighting its potential benefits and adverse outcomes in diabetes management.

Keywords:
CanagliflozinGlycosuriaSGLT1SGLT2Sotagliflozin

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Sodium Glucose Cotransporters 1 (SGLT1) are crucial for glucose absorption in the intestines and reabsorption in the kidneys.
  • SGLT1 activity is particularly relevant in uncontrolled diabetes and in patients using SGLT2 inhibitors.
  • Inhibition of SGLT1 presents a potential therapeutic strategy for managing diabetes.

Purpose of the Study:

  • To review the beneficial and detrimental effects of SGLT1 transporter inhibition.
  • To evaluate the therapeutic potential and risks associated with targeting SGLT1 in diabetes.

Main Methods:

  • Review of existing scientific literature and genetic models of SGLT1 inactivation.
  • Analysis of evidence regarding the impact of SGLT1 inhibition on glucose levels, cardiac tissue, and potential adverse effects.

Main Results:

  • SGLT1 inhibition effectively lowers serum glucose by reducing intestinal and renal glucose reabsorption.
  • Potential benefits include cardiac protection through reduced glycogen and reactive oxygen species.
  • Detrimental effects may include diarrhea, volume depletion, impaired hypoglycemia correction, and euglycemic diabetic ketoacidosis.

Conclusions:

  • SGLT1 inhibition offers a dual effect, presenting both therapeutic advantages and significant risks.
  • The strategy requires careful consideration due to potential adverse events, making it a 'two-edged sword' in diabetes treatment.