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Related Experiment Video

Updated: Feb 5, 2026

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Refractory GERD, beyond proton pump inhibitors.

Sabine Roman1, François Mion1

  • 1Université de Lyon, Hospices Civils de Lyon, Digestive Physiology, Hopital E Herriot, F-69437, Lyon, France; Université de Lyon, Lyon I University, Digestive Physiology, F-69008, Lyon, France; Université de Lyon, Inserm U1032, LabTAU, F-69008, Lyon, France.

Current Opinion in Pharmacology
|September 22, 2018
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Summary
This summary is machine-generated.

For refractory GERD, treatment options include medications, surgery, and alternative therapies. New approaches like potassium-competitive acid blockers and baclofen show promise for managing persistent symptoms and improving patient outcomes.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Refractory gastroesophageal reflux disease (GERD) presents challenges in management.
  • Standard treatments like proton pump inhibitors (PPIs) may not be sufficient for all patients.

Purpose of the Study:

  • To review various therapeutic options for refractory GERD.
  • To explore the efficacy of different pharmacological, surgical, and alternative approaches.

Main Methods:

  • Literature review of pharmacologic therapies, surgical interventions, minimally invasive procedures, and alternative therapies.
  • Analysis of treatment efficacy based on the cause of refractory GERD.

Main Results:

  • Increased acid suppression with PPIs or potassium-competitive acid blockers (P-CABs) may benefit select patients.
  • Baclofen shows efficacy in rumination syndrome, and surgery is a valid option for persistent acid exposure.
  • Dietary changes, breathing exercises, and electrical acustimulation may help with hypersensitivity or functional symptoms.

Conclusions:

  • Treatment selection for refractory GERD should be individualized based on the underlying cause.
  • Emerging therapies like P-CABs and baclofen offer new avenues for managing complex GERD cases.
  • Further research into minimally invasive techniques and alternative therapies is warranted.