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Updated: Feb 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Granular cell tumor in a premenstrual female breast
Lena Omar1, Cory M Pfeifer1, Samir Kulkarni1
1University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, United States of America.
Abstract:
Granular cell tumor is an exceedingly rare pediatric breast mass, derived from Schwann cells which are most commonly observed in the oral cavity, skin, and subcutaneous tissue. When they occur in the breast, they can mimic intrinsic breast masses. Most cases are benign, but malignant cases have been reported. We present a case of a premenstrual, African-American 9 year old female with a painful right breast mass originally felt to be an epidermal inclusion cyst. An ultrasound was performed 17 months after original presentation which demonstrated a 1 cm well-circumscribed solid ovoid mass. Despite the relatively small size and benign imaging appearance of the mass, surgical resection was performed for symptom relief given the associated pain. This is the first known case of granular cell tumor of the breast in a premenstrual female.
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