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[Dynamic single-photon emission computed tomography as a method of identification of multivessel coronary artery

A V Mochula, K V Zavadovsky, S L Andreev

    Vestnik Rentgenologii I Radiologii
    |September 22, 2018
    PubMed

    Insights

    Dynamic tomoscintigraphy effectively detects multivessel coronary artery disease (CAD). Combining it with coronary flow reserve index assessment enhances diagnostic accuracy for coronary circulation issues in CAD patients.

    Area of Science:

    • Cardiology
    • Nuclear Medicine
    • Medical Imaging

    Background:

    • Multivessel coronary artery disease (CAD) poses significant risks.
    • Accurate detection of multivessel CAD is crucial for effective treatment.
    • Current diagnostic methods may have limitations in assessing coronary circulation disturbances.

    Purpose of the Study:

    • To evaluate the diagnostic utility of dynamic tomoscintigraphy in identifying multivessel CAD.
    • To assess the informative value of coronary flow reserve index in CAD detection.

    Main Methods:

    • Dynamic cardiac single photon emission computed tomography (SPECT) with 99mTc-MIBI was performed on patients with multivessel CAD (n=16) and healthy volunteers (n=9).
    • Studies were conducted at rest and during pharmacological stress.
    • Activity-time curves were generated from left ventricular regions of interest to calculate the coronary flow reserve index.

    Main Results:

    • The mean coronary flow reserve index was significantly lower in patients with multivessel CAD (1.39) compared to healthy volunteers (1.86).
    • A coronary flow reserve index below 1.77 indicated three-vessel CAD with 81.8% sensitivity and 66.7% specificity.
    • Dynamic tomoscintigraphy demonstrated potential in detecting multivessel CAD.

    Conclusions:

    • Dynamic tomoscintigraphy, particularly when combined with coronary flow reserve index assessment, enhances the diagnostic value of scintigraphy.
    • This combined approach improves the evaluation of coronary circulation disturbances in patients with multivessel CAD.
    • The method shows promise for improved detection and management of multivessel CAD.
    Abstract

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