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Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
Katsuyoshi Saitou1, Ryuji Ochiai2, Kazuya Kozuma3
1Health Care Food Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan. saitou.katsuyoshi@kao.com.
Nutrients
|September 23, 2018
Summary
Chlorogenic acids (CGAs) supplementation significantly enhanced cognitive functions, including motor speed, psychomotor speed, and executive function, in healthy adults. This suggests CGAs may support brain health and complex task performance.
Area of Science:
- Nutritional Neuroscience
- Human Health & Disease
Background:
- Chlorogenic acids (CGAs) are gaining attention for their potential health benefits.
- Previous research has indicated CGAs' positive effects, prompting further investigation into their impact on human cognition.
Purpose of the Study:
- To evaluate the efficacy of chlorogenic acids (CGAs) in improving cognitive function in healthy human participants.
- To determine if daily CGA supplementation over 16 weeks leads to measurable cognitive enhancements.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 38 healthy participants.
- Participants received either a CGA-added beverage or a placebo daily for 16 weeks.
- Cognitive function was assessed using the Japanese version of CNS Vital Signs (Cognitrax).
Main Results:
- The CGA group demonstrated significant improvements in motor speed, psychomotor speed, and executive function compared to the placebo group.
- Attention shifting test scores also showed significant improvement in the CGA group.
- Blood analysis revealed increased levels of apolipoprotein A1 and transthyretin in the CGA group, which are potential early-stage cognitive decline biomarkers.
Conclusions:
- Daily intake of chlorogenic acids (CGAs) may enhance specific cognitive functions in healthy adults.
- CGAs show potential for supporting cognitive health and improving the performance of complex tasks.
- Further research into CGAs as a dietary intervention for cognitive function is warranted.
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