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Related Concept Videos

Categories of Equilibrium01:30

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Equilibrium is a crucial concept in physics, enabling us to understand how forces interact with bodies to produce no or constant motion. In two-dimensional equilibrium, force systems can be classified into different categories based on their characteristics.
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Related Experiment Video

Updated: Feb 5, 2026

Methylated DNA Immunoprecipitation
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DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.

Adam E Field1, Neil A Robertson2, Tina Wang3

  • 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

Molecular Cell
|September 23, 2018
PubMed
Summary

DNA methylation clocks can measure chronological age and biological aging. Understanding their relationship may reveal new ways to promote healthy aging and longevity.

Keywords:
DNA methylationagingbiological agechronological ageclockepigenetics

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Area of Science:

  • Epigenetics and aging research.
  • Biomarker discovery for age-related diseases.

Background:

  • Age-associated changes in DNA methylation are linked to aging diseases like cancer.
  • DNA methylation clocks correlate epigenetic modifications with chronological age.

Purpose of the Study:

  • To explore the connection between chronological and biological aging clocks.
  • To assess the potential of DNA methylation as a biomarker for healthy aging and disease risk.
  • To investigate mechanisms and interventions for promoting healthy aging and longevity.

Main Methods:

  • Review and synthesis of current research on DNA methylation clocks.
  • Analysis of the relationship between epigenetic aging markers and health outcomes.

Main Results:

  • DNA methylation patterns can serve as both a measure of chronological age and a predictor of biological aging.
  • The concept of a 'biological clock' based on DNA methylation shows promise for assessing health status.

Conclusions:

  • DNA methylation clocks offer insights into aging processes and disease risk.
  • Further research into these clocks could lead to interventions for healthy aging and increased longevity.