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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Related Experiment Video

Updated: Feb 5, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
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Update on corneal neurotisation.

Raman Malhotra1, Mohamed Shafik Elalfy2, Ruben Kannan3

  • 1Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, UK Raman.malhotra1@nhs.net.

The British Journal of Ophthalmology
|September 23, 2018
PubMed
Summary

Corneal neurotisation restores corneal sensation and function by surgically promoting nerve growth. This review details techniques and outcomes for this emerging treatment of neurotrophic keratopathy.

Keywords:
corneanerve graftnerve transferneurotizationneurotrophic keratopathy

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Area of Science:

  • Ophthalmology
  • Neurosurgery
  • Regenerative Medicine

Background:

  • Neurotrophic keratopathy involves impaired corneal sensation and healing.
  • Corneal sensation is crucial for maintaining ocular surface health.
  • Current treatments for severe neurotrophic keratopathy have limitations.

Purpose of the Study:

  • To review the emerging surgical technique of corneal neurotisation.
  • To detail the methods, outcomes, and current understanding of corneal neurotisation.
  • To highlight its potential as a treatment for neurotrophic keratopathy.

Main Methods:

  • Review of existing literature on corneal neurotisation techniques.
  • Analysis of surgical approaches including direct nerve transfer and nerve grafting.
  • Evaluation of reported outcomes and patient results.

Main Results:

  • Corneal neurotisation aims to restore nerve growth into the cornea.
  • Techniques involve coapting donor nerves to recipient corneal nerves.
  • The procedure seeks to improve corneal sensation and trophic support.

Conclusions:

  • Corneal neurotisation is a promising therapeutic strategy.
  • Further research and standardized techniques are needed.
  • It offers potential for restoring corneal health in challenging cases.