Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Golgi Apparatus01:49

Golgi Apparatus

102.3K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
102.3K
Golgi Apparatus01:09

Golgi Apparatus

21.9K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
21.9K
Transport Across the Golgi01:26

Transport Across the Golgi

6.1K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
6.1K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Golgi Matrix Proteins01:12

Golgi Matrix Proteins

2.5K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.5K
Introduction to Special Senses01:26

Introduction to Special Senses

7.5K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations.

The Biochemical journal·2024
Same author

Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.

Traffic (Copenhagen, Denmark)·2024
Same author

The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking.

Journal of cell science·2023
Same author

Arf5-mediated regulation of mTORC1 at the plasma membrane.

Molecular biology of the cell·2023
Same author

A special issue of IUBMB Life celebrating the 50th anniversary of FAOBMB (1972-2022).

IUBMB life·2022
Same author

Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.

FEBS letters·2022

Related Experiment Video

Updated: Feb 5, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

11.4K

The Golgi architecture and cell sensing.

Christian Makhoul1, Prajakta Gosavi1, Paul A Gleeson2

  • 1Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia.

Biochemical Society Transactions
|September 23, 2018
PubMed
Summary

The Golgi apparatus acts as a cell sensor, with its ribbon structure regulating signaling pathways. Loss of this structure is linked to diseases like cancer and neurodegeneration.

Keywords:
Golgi apparatusGolgi ribbonneurodegenerationorganelle structuresignalling

More Related Videos

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex
04:58

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex

Published on: December 3, 2021

8.0K
Imaging Neurons within Thick Brain Sections Using the Golgi-Cox Method
10:26

Imaging Neurons within Thick Brain Sections Using the Golgi-Cox Method

Published on: April 18, 2017

19.3K

Related Experiment Videos

Last Updated: Feb 5, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

11.4K
Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex
04:58

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex

Published on: December 3, 2021

8.0K
Imaging Neurons within Thick Brain Sections Using the Golgi-Cox Method
10:26

Imaging Neurons within Thick Brain Sections Using the Golgi-Cox Method

Published on: April 18, 2017

19.3K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The Golgi apparatus contains signaling molecules like phosphoinositides and GTPases, influencing various cellular pathways.
  • Initially linked to membrane trafficking, Golgi signaling now regulates higher-order cellular functions.
  • The Golgi ribbon structure in vertebrate cells, though enigmatic, is increasingly recognized for its regulatory roles.

Purpose of the Study:

  • To review the emerging role of the Golgi apparatus as a cell sensor.
  • To highlight the connection between Golgi ribbon morphology and signaling network modulation.
  • To discuss the implications of Golgi ribbon fragmentation in diseases.

Main Methods:

  • Literature review of recent advances in Golgi apparatus research.
  • Analysis of signaling pathways associated with Golgi structure and function.
  • Correlation of Golgi ribbon integrity with cellular processes and disease states.

Main Results:

  • Signaling pathways at the Golgi regulate diverse cellular functions beyond membrane trafficking.
  • The Golgi ribbon structure plays a crucial role in regulating cellular processes.
  • Fragmentation of the Golgi ribbon alters multiple signaling pathways.
  • Loss of Golgi ribbon integrity is associated with cancer and neurodegeneration.

Conclusions:

  • The Golgi apparatus functions as a critical cell sensor, integrating morphological status with signaling networks.
  • Maintaining Golgi ribbon architecture is essential for proper cellular function and disease prevention.
  • Further research into Golgi ribbon dynamics offers potential therapeutic targets for associated disorders.