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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Ecological Niches02:02

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All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Related Experiment Video

Updated: Feb 5, 2026

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
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Cellular Interactions in the Intestinal Stem Cell Niche.

Agnieszka Pastuła1,2,3,4,5, Janusz Marcinkiewicz6

  • 1Clinic and Polyclinic for Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

Archivum Immunologiae Et Therapiae Experimentalis
|September 23, 2018
PubMed
Summary
This summary is machine-generated.

Intestinal myofibroblasts regulate the stem cell niche. Understanding this cross-talk aids regenerative medicine and therapies for inflammatory bowel disease, fibrosis, and colorectal cancer.

Keywords:
Inflammatory bowel diseaseIntestinal stem cellsMesenchymal–epithelial cross-talkMyofibroblastsStem cell niche

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Area of Science:

  • Cell Biology
  • Gastroenterology
  • Regenerative Medicine

Background:

  • Epithelial cells are highly proliferative and susceptible to cancer.
  • Connective tissue (mesenchyme) signals are crucial for epithelial development and maintenance.
  • Mesenchymal cells regulate adult epithelial cell regeneration and homeostasis.

Purpose of the Study:

  • To explore the role of intestinal myofibroblasts in the intestinal stem cell niche.
  • To understand the communication between myofibroblasts and intestinal epithelium.
  • To highlight implications for regenerative medicine and disease treatment.

Main Methods:

  • Review of existing literature on myofibroblasts and intestinal stem cells.
  • Analysis of signaling pathways between mesenchymal and epithelial cells.
  • Discussion of the functional role of myofibroblasts in the stem cell niche.

Main Results:

  • Intestinal myofibroblasts are key regulators within the stem cell niche.
  • Myofibroblasts provide essential signals for epithelial cell maintenance and regeneration.
  • Cross-talk between myofibroblasts and epithelium is critical for intestinal homeostasis.

Conclusions:

  • Intestinal myofibroblasts are integral components of the stem cell niche.
  • Understanding myofibroblast-epithelial interactions is vital for advancing regenerative medicine.
  • Targeting this cross-talk may offer new therapeutic strategies for intestinal diseases.