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Hepatitis B problem in Thailand.

C Pramoolsinsap, S Pukrittayakamee, V Desakorn

    The Southeast Asian Journal of Tropical Medicine and Public Health
    |June 1, 1986
    PubMed
    Summary
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    Hepatitis B virus (HBV) infection is widespread in Thailand, affecting millions. Early vaccination and immune globulin significantly reduce HBV transmission in infants born to infected mothers.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Public Health

    Background:

    • Hepatitis B virus (HBV) infection is hyperendemic in Thailand, with 5 million chronic carriers.
    • Prevalence of HBV markers ranges from 40-60% in the general population, increasing with age.
    • Chronic HBV carriers (5-10%) are most prevalent in the 10-30 age group.

    Purpose of the Study:

    • To review the epidemiology of HBV infection in Thailand.
    • To highlight the association between HBV and primary hepatocellular carcinoma (PHC).
    • To assess the impact of interventions on infant HBV infection rates.

    Main Methods:

    • Review of existing epidemiological, clinical, and laboratory studies on HBV in Thailand.
    • Analysis of HBsAg positivity rates in various risk groups and age demographics.

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  • Evaluation of intervention studies using Hepatitis B immune globulin and vaccines.
  • Main Results:

    • HBV infection prevalence increases with age, reaching 40-60% by age 20.
    • 35-75% of adult PHC cases are HBsAg positive; high rates also seen in cirrhosis.
    • Hepatitis B immune globulin and vaccine reduced HBsAg prevalence by 70% and 56% in infants, respectively.

    Conclusions:

    • HBV infection poses a significant public health challenge in Thailand, linked to liver cancer and cirrhosis.
    • Interventions like vaccination are effective in preventing infant HBV transmission.
    • Ongoing research and a national control strategy are crucial for managing HBV in Thailand.