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Updated: Feb 4, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Impact of cellular phosphate handling on vascular calcification
1Divisions of Nephrology and Immunology, Uniklinik RWTH Aachen, Aachen, Germany; Center for Nephrology, Hypertension, and Metabolic Diseases, Hannover, Germany.
Abstract:
Cardiovascular calcification is still a major burden for patients with chronic kidney disease (CKD). The pathomechanism of vascular calcification is complex, involving numerous processes. In this issue, Yamada et al. describe a protective role of Pit-2 within this context by using PiT-2 heterozygous mice with CKD fed a high-phosphate diet. The mechanisms still need to be elucidated. Pit-2 could become a potential therapeutic target.
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