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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
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Ipsilateral ureteroureterostomy: does function of the obstructed moiety matter?
T Kawal1, A K Srinivasan1, R Talwar1
1Pediatric Urology, Children's Hospital of Philadelphia, PA, USA.
Journal of Pediatric Urology
|September 24, 2018
Summary
Ipsilateral ureteroureterostomy (IUU) is a safe surgical option for children with duplex systems and upper pole obstruction. This procedure preserves renal architecture, regardless of the upper pole
Area of Science:
- Pediatric Urology
- Surgical Innovation
- Renal Collecting System Abnormalities
Background:
- Duplex renal collecting systems with upper pole moieties, ureteral ectopia, and ureterocele traditionally undergo upper pole nephrectomy.
- Ablative surgery risks functional loss in the remnant moiety due to vasospasm or vascular injury.
- Ipsilateral ureteroureterostomy (IUU) is explored as an alternative to nephrectomy.
Purpose of the Study:
- To evaluate the safety and feasibility of IUU in managing children with duplex systems and upper pole obstruction.
- To determine if residual function in the obstructed upper pole impacts surgical outcomes.
- To compare outcomes between patients with <10% and ≥10% upper pole moiety function (UPMF).
Main Methods:
- Retrospective review of 53 children with duplex systems undergoing IUU (2010-2016).
- Patients categorized into two groups based on pre-operative UPMF: <10% and ≥10%.
- Outcomes assessed included postoperative complications (Clavien-Dindo), need for secondary surgery, and radiological results.
Main Results:
- No significant differences in postoperative complications, secondary surgery rates, or radiological outcomes were observed between the <10% UPMF and ≥10% UPMF groups.
- Prenatal hydronephrosis was the most common presentation in both groups.
- No patient required secondary surgery.
Conclusions:
- Ipsilateral ureteroureterostomy (IUU) is a safe and definitive surgical intervention for duplex collecting systems.
- IUU effectively preserves renal architecture in pediatric patients.
- The procedure's success is independent of the upper pole moiety's residual function.
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