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Published on: June 13, 2020
Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol2
Rita Sigüeiro1, Julian Loureiro1, Patricia González-Berdullas1
1Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782, Santiago de Compostela, Spain.
Abstract:
As part of our program on synthesis of labeled vitamin D metabolites and analogs, we describe here an efficient and versatile synthetic approach to 28,28,28-trideutero- 25-hydroxydihydrotachysterol2 where isotopic labeling was incorporated stereoselectively in the last step of the synthesis. This deuterated compound will allow the study this analog in vitro or in vivo and to measure AT10-like compounds in serum by LC-MS/MS.
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