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An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
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Common Rodent Flap Models in Experimental Surgery.

Daniel Schmauss1,2, Andrea Weinzierl3,4, Verena Schmauss3

  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerlandschmauss.daniel@gmail.com.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|September 24, 2018
PubMed
Summary
This summary is machine-generated.

Rodent flap models are essential for studying reconstructive surgery complications like tissue necrosis. This review details common models, aiding research into preventing flap failure.

Keywords:
Cremaster flapDorsal skinfold chamberFlap modelsMcFarlane flapOsteomyocutaneous flap

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Area of Science:

  • Surgical Innovation
  • Experimental Surgery
  • Tissue Engineering

Background:

  • Flap procedures are fundamental in reconstructive surgery.
  • Ischemia-related complications, such as tissue necrosis, remain significant challenges.
  • Experimental flap models are crucial for investigating flap physiology and testing preventative strategies.

Purpose of the Study:

  • To provide a comprehensive overview of commonly utilized rodent flap models.
  • To highlight the historical significance and versatility of these models in surgical research.
  • To inform researchers about the selection of appropriate models for specific experimental goals.

Main Methods:

  • Review of established rodent flap models, including cremaster, osteomyocutaneous, McFarlane, ear, and dorsal skinfold chamber.
  • Analysis of the historical development and application of these models.
  • Discussion of the advantages and disadvantages of each model.

Main Results:

  • Rodent flap models are diverse and have a long-standing history in experimental surgery.
  • These models are instrumental for surgical training, understanding flap physiology, anatomy, and vascularity.
  • They facilitate the development of treatments to prevent ischemic tissue necrosis.

Conclusions:

  • Rodent flap models offer valuable insights into flap surgery and the prevention of complications.
  • Researchers must consider model-specific factors like experimental duration, complexity, reproducibility, and clinical translatability.
  • Awareness of these factors is critical for successful and relevant experimental outcomes in flap research.