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Cell Sheet-Based Vascularized Myocardial Tissue Fabrication.

Hyoe Komae1,2, Minoru Ono2, Tatsuya Shimizu3

  • 1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|September 24, 2018
PubMed
Summary

Researchers created thick, functional human myocardial tissue using cell sheet engineering. This scaffold-free method shows promise for regenerative medicine and future cardiac tissue fabrication.

Keywords:
Cell sheetInduced pluripotent stem cellMyocardial tissueVascular bed

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Cardiovascular Research

Background:

  • Advancements in tissue engineering and stem cell research drive regenerative medicine.
  • Artificial organ fabrication is a key goal, offering alternatives to donor transplantation.
  • Current limitations exist for treating diseases requiring organ replacement.

Purpose of the Study:

  • To present a novel method for fabricating functional human myocardial tissue.
  • To demonstrate the efficacy of cell sheet engineering for cardiac tissue construction.
  • To highlight progress towards clinically applicable engineered cardiac grafts.

Main Methods:

  • Utilized cell sheet engineering technology, eliminating the need for scaffolds.
  • Employed a multi-step transplantation procedure, stacking cardiomyocyte sheets onto a vascular bed.
  • Incorporated human-induced pluripotent stem cell-derived cardiomyocytes for tissue construction.

Main Results:

  • Successfully fabricated thick, functional myocardial tissue in vivo and in vitro.
  • Achieved the formation of a vascular network within the engineered myocardial graft.
  • Constructed macroscopically pulsating human myocardial tissue capable of generating pressure.

Conclusions:

  • Cell sheet engineering enables the creation of thick, functional human cardiac tissue.
  • The multi-step transplantation procedure facilitates vascularization crucial for graft survival.
  • While significant progress has been made, further research is needed for clinical translation of engineered cardiac tissues.