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Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Routes of Drug Administration: Enteral01:18

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
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Routes of Drug Administration: Parenteral01:25

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
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Routes of Drug Administration: Overview01:22

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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The Equilibrium Binding Constant and Binding Strength02:18

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The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
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Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats
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Long-Term Constant Subcutaneous Drug Administration.

Shuang Liu1, Maya Miyoshi2

  • 1Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. liussmzk@m.ehime-u.ac.jp.

Methods in Molecular Biology (Clifton, N.J.)
|September 24, 2018
PubMed
Summary
This summary is machine-generated.

A novel long-term drug delivery system using ALZET® osmotic pumps enables continuous, zero-order drug infusion for preclinical research. This method improves efficiency and provides stable drug concentrations, crucial for evaluating antirheumatoid drugs and their safety profiles.

Keywords:
ALZET® osmotic pumpDrug formulationImplantationLong-term drug deliverySubcutaneous administration

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Area of Science:

  • Pharmacology
  • Preclinical Research
  • Drug Delivery Systems

Background:

  • Traditional drug administration in preclinical studies often involves frequent injections, leading to stress and variable drug concentrations.
  • Repeated dosing can be time-consuming and labor-intensive for researchers.
  • Achieving stable drug levels is critical for accurate efficacy and safety assessments.

Purpose of the Study:

  • To introduce a long-term drug delivery system for preclinical therapeutic research.
  • To highlight the advantages of using subcutaneously implanted osmotic pumps for continuous drug infusion.
  • To demonstrate the system's utility in improving preclinical study efficiency and data reliability.

Main Methods:

  • Utilized ALZET® osmotic pumps for subcutaneous implantation.
  • Administered drugs continuously at a zero-order rate.
  • Eliminated the need for external connections and frequent researcher intervention during infusion.

Main Results:

  • Achieved continuous, zero-order drug delivery.
  • Reduced the need for repeated animal handling and injections.
  • Established stable peripheral drug concentrations.
  • Facilitated efficient verification of antirheumatoid drug efficacy.

Conclusions:

  • Subcutaneously implanted osmotic pumps offer a superior method for long-term drug delivery in preclinical research.
  • This system enhances experimental efficiency and provides stable drug concentrations for robust therapeutic evaluation.
  • The technology aids in establishing reliable safety profiles and verifying drug efficacy in preclinical studies.