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Related Concept Videos

Specific Heat01:16

Specific Heat

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The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
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Density, specific weight, specific gravity, and compressibility are fundamental properties of fluids. Density is the mass per unit volume, characterizing the mass of a fluid system. It influences buoyancy, pressure, flow dynamics, viscosity, thermal conductivity, and sound propagation. For instance, in pipeline design, accurate density measurements ensure that the pipeline can handle the fluid's mass.
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
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Specific Gravity of Aggregate01:19

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Aggregates typically contain pores, which can be either permeable or impermeable. Considering the pores in the aggregates, the specific gravity of aggregates is defined in three different forms, namely, bulk or gross specific gravity, apparent specific gravity, and absolute specific gravity.
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Related Experiment Video

Updated: Feb 4, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Generation of Specific Aptamers.

Shuang Liu1, Yasuyuki Suzuki2, Makoto Inui3

  • 1Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. liussmzk@m.ehime-u.ac.jp.

Methods in Molecular Biology (Clifton, N.J.)
|September 24, 2018
PubMed
Summary
This summary is machine-generated.

Nucleic acid aptamers, short DNA or RNA molecules, show promise as therapeutic agents for rheumatoid arthritis due to their high affinity and specificity. The proteoliposome-SELEX method offers a way to develop these potent aptamer drugs.

Keywords:
AptamerPCRProteoliposomeSELEXSingle-strand DNA

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Development

Background:

  • Nucleic acid aptamers are short DNA or RNA oligonucleotides with high affinity and specificity for target molecules.
  • Aptamers offer advantages over antibodies, including ease of synthesis and modification.
  • They have been developed as therapeutic agents, notably for rheumatoid arthritis.

Purpose of the Study:

  • To introduce the proteoliposome-systematic evolution of ligands by exponential enrichment (SELEX) technology.
  • To demonstrate the potential of SELEX in obtaining high-affinity and high-specificity therapeutic agents.

Main Methods:

  • Utilizing a DNA-oligonucleotide pool.
  • Employing the proteoliposome-SELEX technique.

Main Results:

  • The proteoliposome-SELEX method can yield potential therapeutic agents.
  • These agents exhibit high affinity and specificity for their targets.

Conclusions:

  • Proteoliposome-SELEX is a viable technology for aptamer drug discovery.
  • This method facilitates the development of potent aptamer-based therapeutics.