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Expert opinion on emerging urate-lowering therapies
Lisa K Stamp1, Tony R Merriman2, Jasvinder A Singh3,4,5
1a Department of Medicine , University of Otago , Christchurch , New Zealand.
Expert Opinion on Emerging Drugs
|September 25, 2018
Summary
New gout treatments are emerging for managing flares and lowering high uric acid levels. Promising options include arhalofenate for combined action and verinurad for urate lowering, with others in early development.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Gout management has seen a resurgence in therapeutic development.
- Focus is on treating both acute gout flares and chronic hyperuricemia.
Purpose of the Study:
- To summarize novel and emerging therapies for gout management.
- To review treatments targeting serum urate reduction, flare management, or both.
Main Methods:
- Review of new gout therapeutics including urate-lowering agents (ULTs), anti-inflammatory drugs, and combination therapies.
- Categorization of therapies based on their primary mechanism of action: serum urate lowering, flare treatment, or dual action.
Main Results:
- Arhalofenate shows promise for combined urate-lowering and anti-inflammatory effects, pending further data.
- Verinurad is a promising urate-lowering therapy; levotofisopam and ulodesine require more investigation.
- Bucillamine shows potential for flare treatment, needing Phase III studies for efficacy and safety.
- SEL-212 (uricase-replacement therapy) is in Phase II trials.
- Several other ULTs (KUX-1151, UR-1102, FYU-981) are in early development.
Conclusions:
- Several novel therapies are advancing for gout, offering new options for hyperuricemia and flare management.
- Further clinical trials are essential to establish the efficacy and safety profiles of these emerging gout treatments.
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