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Does Axl have potential as a therapeutic target in pancreatic cancer?

Wenting Du1, Rolf A Brekken1

  • 1a Division of Surgical Oncology, Department of Surgery and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas , TX , USA.

Expert Opinion on Therapeutic Targets
|September 25, 2018
PubMed
Abstract

Insights

Targeting Axl, a receptor tyrosine kinase, shows promise for overcoming pancreatic cancer

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Pancreatic cancer is a major cause of cancer mortality.
  • Metastasis, therapy resistance, and immunosuppression are key challenges.
  • Axl receptor tyrosine kinase plays a role in these aggressive tumor characteristics.

Purpose of the Study:

  • To review the role of Axl in normal physiology and cancer.
  • To summarize Axl's regulation and function in pancreatic cancer.
  • To evaluate Axl as a potential therapeutic target.

Main Methods:

  • Literature review of Axl's function in various cancers.
  • Analysis of Axl's contribution to pancreatic cancer hallmarks.
  • Assessment of Axl's therapeutic potential.

Main Results:

  • Axl is implicated in cell plasticity, chemoresistance, immune suppression, and metastasis.
  • Axl contributes to major obstacles in pancreatic cancer treatment efficacy.
  • Limited clinical evidence currently exists for Axl inhibition.

Conclusions:

  • Axl is a promising therapeutic target for pancreatic cancer.
  • Clinical trials are underway to evaluate Axl inhibition combined with standard therapies.
  • Further studies are anticipated to validate Axl as a target.
Keywords:
Axlepithelial plasticityimmunosuppressionmetastasispancreatic cancertherapy resistance

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