Related Experiment Video
Updated: Feb 4, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
Published on: December 8, 2023
Development of Decellularized Cornea by Organic Acid Treatment for Corneal Regeneration
Hung-Jun Lin1, Tsung-Jen Wang2, Ting-Wei Li3
11 Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University , Taipei, Taiwan .
Impact Statement:
This study successfully developed decellularized corneal scaffolds that were prepared by organic acid, which safely exist in animal tissues and plants. The results showed the highly efficient removal of cell debris from porcine corneas, and excellent preservation of optical properties, extracellular matrix (ECM) architecture, and biomolecules. In addition, decellularized corneal scaffolds revealed excellent biocompatibility and recellularization potential in vitro. In an animal model, the transplanted corneas were completely epithelialized, clear, showed no signs of immune response, and effectively supported stromal keratocytes growth. Hence, this could be a promising scaffold material for corneal tissue engineering applications.
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