Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolinic acid: a pathogen in seizure disorders?

R Schwarcz, C Speciale, E Okuno

    Advances in Experimental Medicine and Biology
    |January 1, 1986
    PubMed
    Summary

    Quinolinic acid (QUIN) involvement in human seizures remains circumstantial, as its role in normal brain function is negligible. Further research is needed to understand how this metabolite may cause seizures, particularly in temporal lobe epilepsy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First Constraints on General Neutrino Interactions Based on KATRIN Data.

    Physical review letters·2025
    Same author

    Accurate and reproducible whole-genome genotyping for bacterial genomic surveillance with Nanopore sequencing data.

    Journal of clinical microbiology·2025
    Same author

    Magnetic resonance imaging and ultrasound examination in preoperative pelvic staging of early-stage cervical cancer: post-hoc analysis of SENTIX study.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
    Same author

    Parental conflict driven regulation of endosperm cellularization by a family of Auxin Response Factors.

    Nature plants·2024
    Same author

    The impact of the COVID-19 pandemic on presentation of surgical disease in paediatric patients at a tertiary centre in Cape Town, South Africa.

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2024
    Same author

    Influence of chemoradiation on the immune microenvironment of cervical cancer patients.

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2022

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • Quinolinic acid (QUIN) is a metabolite with suspected involvement in human seizure disorders.
    • QUIN is not a classical neurotransmitter and its role in normal brain function appears minimal.
    • The pathogenic mechanism of QUIN in epilepsy is not well understood.

    Purpose of the Study:

    • To evaluate the current evidence for QUIN's involvement in human seizure disorders.
    • To identify key unanswered questions regarding QUIN's role in temporal lobe epilepsy.
    • To explore potential interactions between QUIN and NMDA-receptors in the brain.

    Main Methods:

    • Review of existing evidence on QUIN's role in neurological disorders.
    • Identification of critical research questions for future investigation.

    Related Experiment Videos

  • Consideration of experimental approaches using NMDA-receptor antagonists.

    • Main Results:

    • Current evidence for QUIN's role in human seizures is circumstantial.
    • Significant knowledge gaps exist regarding QUIN's concentration, metabolism, and regulation in the brain during epilepsy.
    • The modulatory function of NMDA-receptors on brain QUIN requires further investigation.

    Conclusions:

    • A 'quinolinic acid hypothesis' for temporal lobe epilepsy requires substantial further research.
    • Key areas for future study include extracellular QUIN concentrations, brain metabolism, and NMDA-receptor interactions.
    • Experimental use of NMDA-antagonists is crucial for elucidating feedback mechanisms involving QUIN.