Related Experiment Video

Updated: Feb 4, 2026

Experimental Human Pneumococcal Carriage
07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

16.3K

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) in healthy infants

David Greenberg1, Patricia A Hoover2, Timo Vesikari3

  • 1Soroka University Medical Center, Beer-Shiva, Israel.

Vaccine
|September 25, 2018
PubMed

Insights

The 15-valent pneumococcal conjugate vaccine (PCV15) showed a safety profile comparable to PCV13 in infants. PCV15 induced robust immune responses to all 15 serotypes, demonstrating its potential for broader protection against pneumococcal disease.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatric Infectious Diseases

Background:

  • Pneumococcal conjugate vaccines (PCV) have reduced disease burden but led to increased disease from non-vaccine serotypes.
  • Evaluating new vaccines is crucial to broaden protection against emerging pneumococcal serotypes.

Purpose of the Study:

  • To assess the safety and immunogenicity of a 15-valent pneumococcal conjugate vaccine (PCV15) in infants.
  • To compare PCV15, including novel serotypes 22F and 33F, against the existing 13-valent PCV (PCV13).

Main Methods:

  • Infants received PCV15 (adjuvanted or nonadjuvanted) or PCV13 at 2, 4, 6, and 12-15 months.
  • Safety was monitored for 14 days post-vaccination.
  • Immunogenicity assessed via IgG GMCs and OPA GMTs at multiple time points.

Main Results:

  • Safety profiles were similar across all vaccine groups.
  • PCV15 demonstrated non-inferiority to PCV13 for 10 of 13 shared serotypes based on IgG GMCs.
  • PCV15 induced higher antibody responses to serotypes 3, 22F, and 33F compared to PCV13.

Conclusions:

  • PCV15 exhibits an acceptable safety profile in infants.
  • The vaccine elicits robust immune responses (IgG and OPA) to all 15 serotypes.
  • PCV15 offers comparable immunogenicity to PCV13 for most shared serotypes, with enhanced responses to new serotypes.
Abstract

Keywords:
ImmunogenicityPneumococcal conjugate vaccineSafety

More Related Videos

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells12:54

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

2.4K
Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay09:20

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Published on: April 28, 2014

13.1K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
51.7K
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
28.8K
Conjugated Proteins02:50

Conjugated Proteins

3.2K
Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
793
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
398
Conjugation01:19

Conjugation

Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
2.4K