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Miller Fisher Syndrome Associated With Immunotherapy for Metastatic Melanoma

Jonathan J D Baird-Gunning1, Dinushi Weerasinghe2, Matthew Silsby2

  • 1Department of Neurology, Canberra Hospital, Garran, Australian Capital Territory, Australia.

The Neurohospitalist
|September 25, 2018
PubMed

Immunotherapy is a treatment strategy that has demonstrated survival benefit for metastatic melanoma. Ipilimumab and nivolumab are examples of immunotherapy, in which monoclonal antibodies antagonize cytotoxic T-lymphocyte-associated protein 4 and programmed death-ligand 1 receptors, respectively, resulting in upregulation of the host immune response to cancer cells. There is increasing recognition of immune-mediated adverse events associated with immune therapies in patients with cancer. We present a case report of a patient who developed Miller Fisher syndrome associated with these therapies for metastatic melanoma along with a discussion of its management.

Keywords:
CTLA-4 receptorMiller-Fisher syndromePD-1 receptorimmunotherapymelanoma

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