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Lodderomyces elongisporus: a bloodstream pathogen of greater clinical significance

K Al-Obaid1, S Ahmad2, L Joseph2

  • 1Department of Microbiology, Mubarak Al-Kabeer Hospital, Kuwait.

New Microbes and New Infections
|September 25, 2018
PubMed

Insights

Lodderomyces elongisporus is an emerging fungal pathogen causing bloodstream infections. Accurate identification using molecular methods is crucial, as traditional systems may underestimate its clinical significance.

Area of Science:

  • Medical Mycology
  • Clinical Microbiology
  • Infectious Diseases

Background:

  • Lodderomyces elongisporus is often misidentified by the VITEK 2 system, underestimating its clinical relevance.
  • Invasive fungal infections pose a significant threat, particularly in vulnerable populations.

Purpose of the Study:

  • To highlight the underestimation of Lodderomyces elongisporus as a clinical pathogen.
  • To report a case of primary progressive fungemia caused by L. elongisporus.
  • To emphasize the need for accurate identification methods.

Main Methods:

  • Case report of fungemia.
  • Identification of the causative agent using PCR sequencing of the ribosomal DNA internally transcribed spacer region.
  • Literature review on L. elongisporus bloodstream infections.

Main Results:

  • A fatal case of primary progressive fungemia due to L. elongisporus in an immunocompetent patient.
  • The VITEK 2 system failed to accurately identify the yeast.
  • Molecular identification confirmed L. elongisporus.
  • The patient did not respond to caspofungin treatment and died within 3 days.

Conclusions:

  • Lodderomyces elongisporus is an emerging bloodstream pathogen with significant clinical implications.
  • Accurate identification of L. elongisporus requires molecular methods beyond traditional phenotypic systems.
  • Early and correct diagnosis is critical for effective management of L. elongisporus infections.
Keywords:
Ascosporesbloodstream pathogenemerging significancelodderomyces elongisporusmolecular identification

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