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Updated: Feb 4, 2026

Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
Published on: August 11, 2014
Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells
Tong Zhang1, Min Li2, Xiaotong Wang1
1State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China. yuanwei7568@163.com.
Abstract:
Magnetic poly(l-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin-biotin amplification system as artificial antigen-presenting cells. The activation of T cells was enhanced significantly due to the surface topographic structure and increased signal molecule amount.
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